Bowel cancer, also known as colorectal cancer, is an umbrella term used to describe cancers of the large bowel/intestine (colon and rectum) (Cancer Council Victoria 2021).
Depending on which part of the large bowel is affected, the cancer may be referred to more specifically as colon cancer or rectal cancer, although the two are often grouped together due to their similarities (ACS 2020).
It’s the fourth most common type of cancer in Australia (excluding non-melanoma skin cancers) after prostate cancer, breast cancer and melanoma of the skin, with about 15,400 diagnoses made annually (AIHW 2023).
The colon and rectum, which together form the large bowel, are part of the gastrointestinal system (ACS 2020).
The colon is a 1.5-metre-long muscular tube that absorbs water and nutrients from partially digested food, leaving behind waste (faeces) that is then passed into the rectum. Faeces is stored in the rectum until it is excreted through the anus during a bowel movement (ACS 2020; Better Health Channel 2021).
Most bowel cancers develop from polyps - clumps of cells that form on the intestinal mucosa (Cancer Council Victoria 2021; Mayo Clinic 2023).
Polyps are common, developing in about 25% of people aged over 50 (NHS 2023). While polyps are initially benign, and most remain harmless, some - particularly adenomatous polyps (adenomas) - may become cancerous if left alone (Cancer Council Victoria 2021; ACS 2020).
Polyps may resemble flat spots on the intestinal lining or raised growths that appear to be suspended by a ‘stalk’ (Better Health Channel 2021; Bowel Cancer Australia 2018).
While 90% of bowel cancers are caused by adenocarcinomas (adenomas that become cancerous) (Better Health Channel 2021; Cleveland Clinic 2021), there are other rare types of bowel cancer, including:
(Better Health Channel 2021)
Risk factors include:
(Better Health Channel 2021; Cancer Council Victoria 2021)
Bowel cancer may cause no symptoms in its early stages. When symptomatic, it may cause:
(Cancer Council Victoria 2021)
It’s important to note that changes in bowel movements are normal, and these symptoms don’t necessarily indicate cancer. Differential diagnoses include haemorrhoids, diverticulitis, inflammatory bowel disease and anal fissure. However, any amount of bleeding is a red flag and should be escalated (Cancer Council Victoria 2021).
About half of all bowel cancer cases in Australia aren’t detected early enough for treatment to be successful. This is a major reason why bowel cancer is the second biggest cause of cancer deaths in Australia (Healthdirect 2020).
The National Bowel Cancer Screening Program uses an immunochemical faecal occult blood test (iFOBT) to detect traces of blood in stools, which is a potential sign of bowel cancer even before the onset of symptoms (DoHaAC 2023).
The screening test is free and can be performed at home. It’s mailed to all eligible Australian people between the ages of 50 and 74 every two years, with the aim of identifying possible bowel cancer cases early (DoHaAC 2023).
If a patient returns a positive bowel screening test or is experiencing symptoms of bowel cancer, the following diagnostic tests may be performed:
(Better Health Channel 2021; Cancer Council Victoria 2021)
Bowel cancer typically doesn’t spread quickly. Polyps may take several years to become cancerous (Healthdirect 2020).
In Australia, the most commonly used staging system is TNM (tumour-nodes-metastasis). The Australian Clinico-Pathological Staging (ACPS) system may also be used (Cancer Council NSW 2023).
| TNM | Description |
|---|---|
| Stage I | Cancerous cells are only present in the inner layers of the bowel wall. |
| Stage II | Cancerous cells have spread deeper into the layers of the bowel wall. |
| Stage III | Cancerous cells are present in any layer of the bowel wall and have spread to nearby lymph nodes. |
| Stage IV | Cancerous cells have spread to other parts of the body (e.g. lungs, liver or distant lymph nodes). |
(Adapted from Cancer Council NSW 2023)
Treatment depends on how far cancer has already progressed, as well as the patient’s health status and preferences (Healthdirect 2020).
Colon cancer and rectal cancer are also treated differently (Cancer Council Victoria 2021).
Colon cancer is best treated surgically if at an early or locally advanced stage. The patient will typically undergo a colectomy, wherein the cancerous area, as well as a normal area of the bowel and nearby lymph nodes, are surgically removed (Cancer Council Victoria 2021).
During the procedure, the bowel will be cut on either side of the cancerous portion along with a border of healthy tissue. The two remaining ends will then be joined together (a procedure known as anastomosis) (Cancer Council Victoria 2021).
There are different types of colectomies that can be performed depending on what part of the colon needs to be removed. In some cases, the entire colon and rectum will be excised (Cancer Council Victoria 2021).
Some patients may also need to undergo a colostomy or ileostomy (Cancer Council Victoria 2021). The stoma may be temporary or permanent (Better Health Channel 2021).
If the cancer has already spread to the lymph nodes, the patient might need to undergo chemotherapy after the colectomy (Cancer Council Victoria 2021).
Early rectal cancer is also typically treated surgically. However, if cancer has spread beyond the rectal wall and into nearby lymph nodes, the patient may need to undergo chemotherapy or chemoradiation (combined chemotherapy and radiation therapy) before surgery. There may also be further chemotherapy or radiation therapy after the surgery (Cancer Council Victoria 2021).
The exact surgical procedure will depend on where the cancer is located and whether the bowel can be rejoined. It will be performed as either an open or keyhole surgery (Cancer Council Victoria 2021).
The most common procedures are anterior resection and abdominoperineal resection. If the cancer is in a very early stage or the patient is unable to undergo major surgery, a local excision might be performed instead via an instrument inserted into the anus (Cancer Council Victoria 2021).
Advanced bowel cancer (i.e. stage IV) may require a combination of chemotherapy, targeted therapy, radiation therapy, surgery and palliative care (Cancer Council Victoria 2021).
The most recent statistics indicate that in Australia, about 71% of people will survive for at least five years after their bowel cancer diagnosis (relative to the general Australian population) (Cancer Australia 2023).
The patient’s exact prognosis will depend on a number of factors, including:
(Cancer Council Victoria 2021)
If detected early, bowel cancer can be successfully treated in over 90% of cases (DoHaAC 2023).
Therefore, initiatives like the National Bowel Cancer Screening Program are crucial in ensuring bowel cancer is caught as early as possible.
About 32 to 44% of people with bowel cancer experience psychological distress following their diagnosis, especially those with a stoma in situ (Cancer Council VIC & DoH VIC 2021).
This can be caused by a variety of factors, including the physical symptoms of the illness (e.g. pain), low self-esteem due to having a stoma and distress related to the diagnosis and treatment (Cancer Council VIC & DoH VIC 2021).
It’s important to consider the psychological impact a diagnosis of bowel cancer may have on the patient and their family, be open and encouraging of discussion related to this and provide support where necessary. You should also ensure patients and their families are appropriately informed about their diagnosis, symptoms and treatment options (Cancer Council VIC & DoH VIC 2021).
Keep in mind, also, that patients with bowel cancer may require supportive care related to:
(Cancer Council VIC & DoH VIC 2021)
The risk of bowel cancer can be reduced by:
(Cancer Council Victoria 2021)
Question 1 of 3
Cancerous cells that have spread to nearby lymph nodes would be at what stage?
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